p53 and the Sin of Pride (Proverbs 6:16-19)

p53 is the most commonly mutated gene in cancers. Its normal function is to regulate apoptosis, a sophisticated mechanism that controls the death of cells. To cite a very few examples of the ubiquitous nature of this gene, whenever we shed hair, skin, or renew our blood cells, p53 is involved. But when p53 is mutated or altered, it loses this ability and allows the cell mechanisms to run amuck, growing out of control. The result may be cancer or a process that will lead the cell to an eventual cancer.

The Bible lists many sins but perhaps none is more devastating than pride. Like p53, it is ever present and involved in nearly every type of sin. The origins of pride can arise with very noble intentions. It is important to take pride in one’s work, in one’s appearance, in the character and honesty of one’s relationships. But like p53, if this balance goes awry, our pride can become envy, jealousy, vanity, and insecurity.

These six things the Lord hates, yes, seven are an abomination to Him: a proud look, a lying tongue, hands that shed innocent blood, a heart that devises wicked plans, feet that are swift in running to evil, a false witness who speaks lies, and one who sows discord among brethren.
Proverbs 6:16-19

Why does God place a proud look or pride as the first sin that He hates? In many instances, pride can lead to the other six sins that God hates. Think about how many people in the Bible have fallen because of their pride-Saul, Samson, and Hamman, just to list a few. Even in one the shortest books of the Bible, 3 John, Diotrephes is singled out as a member of the church who “loves to have the preeminence” (verse 9).

The sin of pride should remind us how easy it is to lose our balance and focus upon God. If we do, like a mutation in p53, we can allow our lives to careen down a destructive path, far removed from the plan of peace and contentment that God desires for all of us.

Love and respect the Lord; seek His Will in your life.